At Glendale, Arizona:
Quarterback Alex Smith completed 18 of 19 passes for 232 yards and three touchdown---two to Michael Crabtree (three and nine yards) and one to Randy Moss (47 yards)---as the San Francisco 49ers (6-2) opened up a two-game lead atop the NFC Western Division standings following their 24-3 Monday night road domination of the Arizona Cardinals (4-4).
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